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Search Result

Search Results for " hif/hif prolyl-hydroxylase "

20

Compounds

Cat No. Product Name Synonyms Targets
T64336 Izilendustat HIF/HIF Prolyl-Hydroxylase
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.
T6S0071 Fraxinellone HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...
T22022 Adaptaquin HIF
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
T3169 KC7F2 HIF/HIF Prolyl-Hydroxylase , HIF
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T11561 HIF-2α-IN-2 HIF/HIF Prolyl-Hydroxylase , HIF
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T0244 Tilorone dihydrochloride Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T50099 HIF-2α-IN-4 Others , HIF/HIF Prolyl-Hydroxylase
HIF-2a translation inhibitor is a compound used as a molecular building block.
T21653 1,4-DPCA HIF/HIF Prolyl-Hydroxylase
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
T5392 TP0463518 HIF/HIF Prolyl-Hydroxylase
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T7880 IOX4 HIF/HIF Prolyl-Hydroxylase
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T13398 ZINC13466751 HIF
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM).
T7848 PT-2385 HIF/HIF Prolyl-Hydroxylase , HIF
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T13050 SYP-5 HIF/HIF Prolyl-Hydroxylase , HIF
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T5537 IDF-11774 HIF/HIF Prolyl-Hydroxylase , HIF
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T12675L PT2399 HIF/HIF Prolyl-Hydroxylase , HIF
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM).
T3180 JNJ-42041935 HIF-PHD Inhibitor II HIF/HIF Prolyl-Hydroxylase
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
T4106 MK-8617 MK8617 HIF/HIF Prolyl-Hydroxylase
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
T2488 BAY 87-2243 Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T29797 AKB-6899 AKB6899 VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...
T15219 Enarodustat JTZ-951 Others , HIF/HIF Prolyl-Hydroxylase
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
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